To begin, we have a Naive B cell in the G-zero phase (Picture 1).
Picture 1.
Next, we have a naive B-cell that has begun it's path down the thymus-dependent maturation route (picture 2). The green bits are antigen.
Picture 2.
Here, the naive B cell has been activated with signal 2 (picture 3). As the cell progress from the G1 to the S phase, I envision the endoplastic reticulum sorta increasing in sheaths. Note too that they can now be influenced by IL to change isotypes?
Picture 3. Aka centroblast...?
Picture 4.
Picture 5.
Picture 2: To be nitpicky.. (again) I don't know if we can classify the B cell as naive if it's shown with antigen on it?
ReplyDeletehttp://en.wikipedia.org/wiki/Naive_B_cell
Picture 3: I think isotype switching also needs a Th-cell interaction, which implies the B cell is presenting antigen (and wouldn't be naive..)
We could say something along the lines of early activated; antigen-bound low specificity b cell; antigen-exposed early b cell...
*scratches head*
Though you might have a more reputable source than wikipedia!
ReplyDelete(I don't know much about the G0, G1 and S phases..)
So... would theterm "competent" work then?
ReplyDeleteSignal 1/2 are both "competence" signals...
ReplyDeleteYes! Competent.. much more (didactic)
ReplyDelete